J.A. Harker

Differentiation of human T follicular helper cells in vitro requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2

This study shows that human T follicular helper cells differentiate in vitro through STAT3 and SMAD cytokine cooperation, but IL-2 inhibits this process.

Therapeutic ICOS blockade reduces T follicular helper cells and improves allergic airway disease

This study shows that blocking ICOS reduces T follicular helper cells and alleviates allergic airway disease in mice by impairing germinal center responses and reducing allergen-specific IgE.