Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception
Kijung Sung, Luiz F. Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L. Pearn, Michael T. Maloney, William Cary Mobley, Jon D. Levine, Chengbiao Wu
This study investigates the NGFR100W mutation in NGF, showing it supports neuronal survival via TrkA but fails to activate p75NTR, distinguishing trophic from nociceptive signaling.
Journal of Neuroscience · Feb 26, 2018Peer-reviewedNeuroscience