Sex- and age-dependent control of dopamine function by LRRK2, and rapid reversal of dopamine release deficits in the LRRK2-G2019S knock-in mouse model of Parkinson's Disease.
Christina Gentle, Anusha Kamesh, Jeanne F. Madranges, Sean Coady, Bruno Freitas Jorge Vieira, Camila Tiefensee Ribeiro, Sean McClean, Naila Kuhlmann, Anouar Khayachi, Alessia Pietrantonio, Lorèns Moulanier, Eli Cohen, Matthew James Farrer, Matthew Parsons, Austen J. Milnerwood
The paper investigates how LRRK2 activity affects dopamine release in mice, showing age- and sex-dependent changes and rapid reversal with inhibition in certain groups.
bioRxiv · Oct 16, 2026 · PreprintNeuroscience