Microglia produce the amyloidogenic ABri peptide in familial British dementia
Charles Arber, Jackie M. Casey, Samuel Crawford, Naiomi Rambarack, Ümran Yaman, Sarah Wiethoff, Emma Augustin, Thomas M. Piers, Matthew Price, Agueda A. Rostagno, Jorge A. Ghiso, Patrick Alfryn Lewis, Tamás Révész, John Hardy, Jennifer M. Pocock, , Selina Wray
This study shows microglia produce ABri peptide in FBD, contributing to amyloid plaques and neurodegeneration, and suggests ITM2B/BRI2 is involved in microglial disease responses.
Acta Neuropathologica · Nov 15, 2024Peer-reviewedNeuroscience