Author

Jackie M. Casey

UCL Queen Square Institute of NeurologyORCID 0000-0002-1447-8377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Selina WrayiD· 3 shared Charles ArberiD· 2 shared Dervis A. M. SalihiD· 2 shared John HardyiD· 2 shared Aaron HeldiD· 1 shared Agueda A. RostagnoiD· 1 shared Ana‐Caroline RauliniD· 1 shared Andrian YangiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Selina WrayORCID

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3 papers

Recent·Most cited

NeuroscienceMolecular NeurodegenerationPeer-reviewedJun 20, 2025

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Oliver Jonathan Ziff, Gustavo Morrone Parfitt, Sarah Jolly…·Charles Arber

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceActa NeuropathologicaPeer-reviewedNov 15, 2024

Microglia produce the amyloidogenic ABri peptide in familial British dementia

Charles Arber, Jackie M. Casey, Samuel Crawford…·Selina Wray

This study shows microglia produce ABri peptide in FBD, contributing to amyloid plaques and neurodegeneration, and suggests ITM2B/BRI2 is involved in microglial disease responses.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceCell stem cellPeer-reviewedDec 1, 2022

A reference induced pluripotent stem cell line for large-scale collaborative studies

Caroline B. Pantazis, Andrian Yang, Erika Lara…·Florian T. Merkle

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

323 citationstop 1%

humanwhole-genome sequencing

𝕏 PostBluesky