Author

Jorge A. Ghiso

New York UniversityORCID 0000-0002-0870-0437Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Agueda A. RostagnoiD· 2 shared John HardyiD· 2 shared André StrydomiD· 1 shared Anne Rovelet‐LecruxiD· 1 shared Annette Karmiloff‐Smith· 1 shared Aoife MurrayiD· 1 shared Carla Marie StartiniD· 1 shared Charles ArberiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersNeuroscience

Agueda A. RostagnoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Microglia produce the amyloidogenic ABri peptide in familial British dementia

Charles Arber, Jackie M. Casey, Samuel Crawford, Naiomi Rambarack, Ümran Yaman, Sarah Wiethoff, Emma Augustin, Thomas M. Piers, Matthew Price, Agueda A. Rostagno, Jorge A. Ghiso, Patrick Alfryn Lewis, Tamás Révész, John Hardy, Jennifer M. Pocock, , Selina Wray

This study shows microglia produce ABri peptide in FBD, contributing to amyloid plaques and neurodegeneration, and suggests ITM2B/BRI2 is involved in microglial disease responses.

Acta Neuropathologica · Nov 15, 2024Peer-reviewedNeuroscience

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Ying Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh Louise O’Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, Norris Ray Dunn, , Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

Molecular Psychiatry · Jul 9, 2020Peer-reviewedNeuroscience