The fat-body secreted neuropeptide CCHa2 signals insulin-producing cells in the brain to promote sleep
Samaneh Biglari, Shangyu Gong, Miranda C. Wang, Ciara A. Payne, Matthew R. Kauffman, Justin R. DiAngelo, Alex C. Keene
This study identifies CCHa2 as a neuropeptide secreted by the fat body that signals insulin-producing cells in the brain to regulate sleep in Drosophila.
bioRxiv · Nov 25, 2025 · PreprintNeuroscience