A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export
Pankaj Kumar, Phillip A. Hyon, Rishi Nixon, Ashley V. Bullington, Ciara A. Payne, Iris Lindberg, Daniel L. Kober
The paper determines the structure of an immature proPC1/3 variant and identifies a conformational checkpoint for ER export, explaining the functional impact of PCSK1 mutations.
bioRxiv · Jul 22, 2026 · PreprintBiochemistry