Samaneh Biglari

This study shows that Drosophila with APOE4 variants exhibit AD-like phenotypes under stress and metabolic challenges, supporting a multi-hit model of disease.

The paper identifies cell-type-specific genes regulating sleep by mapping GWAS variants to effector genes in human and Drosophila models, revealing ruby/AP3B2 as a conserved glial regulator.

This study identifies CCHa2 as a neuropeptide secreted by the fat body that signals insulin-producing cells in the brain to regulate sleep in Drosophila.

This study shows that blood-derived dietary protein increases sleep and reduces activity in Aedes aegypti mosquitoes, suggesting a role for protein in regulating postprandial sleep behavior.