Genesis and regulation of C-terminal cyclic imides from protein damage
Wenqing Xu, Zhenguang Zhao, Matthew Su, Atul D. Jain, Hannah C. Lloyd, Ethan Yang Feng, Nick Cox, Christina M. Woo
The paper investigates C-terminal cyclic imides as protein damage products, their formation mechanisms, and their impact on protein stability and quality control via CRBN.
Proceedings of the National Academy of Sciences · Dec 30, 2024Peer-reviewedBiochemistry