Wenqing Xu

The paper identifies PCMT1 as an enzyme that forms C-terminal cyclic imides on CRBN substrates, linking it to metabolic enzyme regulation and epileptic phenotypes.

This paper introduces a method called cerebody to detect and enrich endogenous cereblon substrates by targeting C-terminal cyclic imide modifications.

The paper investigates C-terminal cyclic imides as protein damage products, their formation mechanisms, and their impact on protein stability and quality control via CRBN.