Christina M. Woo

This study shows that molecular glue degraders targeting CK1 can co-degrade multiple SACK1 proteins, highlighting the role of protein complex context in targeted protein degradation.

The paper identifies PCMT1 as an enzyme that forms C-terminal cyclic imides on CRBN substrates, linking it to metabolic enzyme regulation and epileptic phenotypes.

This paper introduces a method called cerebody to detect and enrich endogenous cereblon substrates by targeting C-terminal cyclic imide modifications.

The paper investigates C-terminal cyclic imides as protein damage products, their formation mechanisms, and their impact on protein stability and quality control via CRBN.

This study shows that the schizophrenia-associated SLC39A8 variant A391T alters N-glycosylation in the mouse brain, affecting glycoproteins involved in schizophrenia-related pathways.