Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature
Matthias Hehl, Myriam Scherer, Cora Stegmann, Eva-Maria Raubuch, Claudia Ploil, Teresa Rummel, Philipp Kirchner, Nina Kottmann, Anna Reichel, Anna Katharina Kuderna, Anne-Charlotte König, Caroline C. Friedel, Florian Erhard, Thomas Stamminger
This study identifies ISG20 as an antiviral factor against HCMV by inducing an innate immune defense signature that enhances IFN production and response.
PLoS Pathogens · Jan 9, 2026Peer-reviewedMicrobiology