Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodeling
Agnieszka A. Gorska, Clara Sandmann, Eva Riechert, Christoph P. Hofmann, Ellen Malovrh, Eshita Varma, Vivien Kmietczyk, Lonny Jürgensen, Verena Kamuf‐Schenk, Claudia Stroh, Jennifer Furkel, Matthias Konstandin, Carsten Sticht, Etienne Boileau, Christoph Dieterich, , Mirko Völkers
The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.
bioRxiv · Nov 29, 2020 · PreprintMolecular Biology