Clara Sandmann

Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes

The paper examines the relationship between the ER and SR in cardiac myocytes, finding that the SR becomes the primary site of protein synthesis in adult cells, while the ER retains specialized functions.

Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response

This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.

Age-related decline of the unfolded protein response in the heart promotes protein misfolding and cardiac pathology

This study shows that the unfolded protein response declines with age in the heart, leading to protein misfolding and cardiac dysfunction.

Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodeling

The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.