Vivien Kmietczyk

ZEB1 Is a Key Regulator of Cardiomyocyte Structure and Function

This study investigates ZEB1's role in cardiomyocyte structure and function, finding that its deletion causes sarcomere damage, mitochondrial dysfunction, and dedifferentiation, particularly in females.

Ythdf2 regulates cardiac remodeling through its m6A-mRNA target transcripts

This study shows that Ythdf2, an m6A reader protein, regulates cardiac function by controlling gene expression through its target transcripts, leading to cardiac remodeling in heart failure models.

Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodeling

The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.