Lonny Jürgensen

This study shows that Ythdf2, an m6A reader protein, regulates cardiac function by controlling gene expression through its target transcripts, leading to cardiac remodeling in heart failure models.

This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.

The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.

The paper compares transcriptome and translatome networks in cardiac remodeling to identify differences in gene regulation and functional modules.

The paper identifies extracellular vesicles (EVs) as a mechanism for transporting BMP2/4 during zebrafish embryonic development, leading to dorsalization phenotypes when EV secretion is inhibited.