Promiscuous and multivalent interactions between Eps15 and partner protein Dab2 generate a complex interaction network.
Andromachi Papagiannoula, Ida Marie Vedel, Kathrin Motzny, Maud Tengo, Arbesa Saiti, Sigrid Milles
The paper investigates Eps15's EH domains interactions with Dab2 and its own IDR, revealing promiscuous binding and a self-inhibitory mechanism that facilitates endocytosis.
Nature Communications · Aug 21, 2025Peer-reviewedBiophysics