Sigrid Milles

This study elucidates how AlbA, an antibiotic resistance factor, activates transcription in response to albicidin by remodeling promoter architecture and facilitating a kinetic transition to promoter opening.

This study shows how transient secondary structure in intrinsically disordered regions can generate new molecular functions while preserving ancestral activities in paralogous proteins.

The paper designs a binary fluorescent turn-on probe using a HaloTag mutant and a difluorinated xanthene ligand for covalent labeling and imaging applications.

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

This study shows that protein condensates and clathrin assembly regulate each other during clathrin-mediated endocytosis, enhancing vesicle formation while controlling condensate growth.

The paper investigates Eps15's EH domains interactions with Dab2 and its own IDR, revealing promiscuous binding and a self-inhibitory mechanism that facilitates endocytosis.