Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential
Simone L. Park, Mark M. Painter, Sasikanth Manne, Víctor Alcalde, Maura McLaughlin, Matthew A. Sullivan, Divij Mathew, Leonel Torres, Yinghui Huang, David B. Reeg, Naomi R. Douek, Trenton Campos, Max Klapholz, Maria Andrea Cardenas, Victoria Fang, , E. John Wherry
The paper identifies TR-TEX cells as distinct from TRM cells, showing they have unique transcriptional regulation and respond differently to PD-1 inhibition.
bioRxiv · Aug 8, 2025 · PreprintImmunology