Author
University of PennsylvaniaORCID 0000-0001-9856-0871Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Mark M. Painter, David B. Reeg, Naomi R. Douek…·E. John Wherry
The paper identifies persistently activated virus-specific CD8 T cells in long COVID patients, suggesting chronic antigen stimulation by SARS-CoV-2 or herpesvirus.
Shin Foong Ngiow, Ryan P. O’Connell, Sasikanth Manne…·E. John Wherry
The paper shows that a drug holiday during PD-1 blockade improves reinvigoration of exhausted T cells by restoring progenitor cell function and reducing adaptive resistance.
Ping Wang, Josephine Ruth Giles, Hua Huang…·E. John Wherry
The paper develops a CRISPRi platform to annotate functional enhancers in human T cells, identifying novel CREs and their regulatory roles in immune responses.
Simone L. Park, Mark M. Painter, Sasikanth Manne…·E. John Wherry
The paper identifies TR-TEX cells as distinct from TRM cells, showing they have unique transcriptional regulation and respond differently to PD-1 inhibition.
Hua Huang, Amy E. Baxter, Zhen Zhang…·E. John Wherry
This study identifies how histone modifications regulate gene expression in memory and exhausted CD8 T cells, revealing distinct epigenetic programs between these cell types.