Víctor Alcalde

In vivo reprogramming of cytotoxic effector CD8+ T cells via fractalkine-conjugated mRNA-LNP

This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.

PD-1 blockade drug holiday improves exhausted progenitor CD8 T cell (Tpex) reinvigoration by avoiding Tpex adaptive resistance

The paper shows that a drug holiday during PD-1 blockade improves reinvigoration of exhausted T cells by restoring progenitor cell function and reducing adaptive resistance.

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

The paper identifies TR-TEX cells as distinct from TRM cells, showing they have unique transcriptional regulation and respond differently to PD-1 inhibition.

Identification and drug-induced reversion of molecular signatures of Alzheimers disease onset and progression in AppNL-G-F, AppNL-F and 3xTg-AD mouse models

The paper identifies molecular signatures of Alzheimer's disease in AD mouse models and finds drugs that reverse these signatures and cognitive impairment.

Bioactivity descriptors for uncharacterized compounds

The paper introduces deep neural networks to infer bioactivity signatures for uncharacterized compounds, improving activity prediction across various biological endpoints.

Extending the small molecule similarity principle to all levels of biology

The paper introduces Chemical Checker, a resource that integrates bioactivity data on 800,000 small molecules and demonstrates its use in drug discovery and disease modeling.