Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation.
Jérôme Ezan, Maïté Marie Moreau, Tamrat M. Mamo, Miki Shimbo, Maureen Decroo, Melanie Richter, Ronan Peyroutou, Rivka A. Rachel, Fadel Tissir, Froylán Calderón de Anda, Nathalie Sans, Mireille Montcouquiol
This study shows that Scrib deletion in mice causes cortical thinning, disrupted connectivity, and psychomotor deficits, linking Scrib to neurodevelopmental disorders.
Scientific Reports · Apr 27, 2021Peer-reviewedNeuroscience