FMRP regulates adult human cortical neuron excitability via cyclic-AMP signalling
Max J J Knops, Soraya Meftah, Max A Wilson, Lewis W. Taylor, Calum Bonthron, Alsadeg Bilal, Imran Liaquat, Paul Martin Brennan, Claire S. Durrant, Sam A. Booker
This study shows that FMRP depletion in human neurons causes cyclic-AMP-dependent hyperexcitability, which can be corrected by inhibiting phosphodiesterase 4D.
bioRxiv · Oct 14, 2025 · PreprintNeuroscience