Soraya Meftah

This study identifies reduced inhibition, bursting, and accelerated oscillations as drivers of early hippocampal hyperactivity in Alzheimer's disease using in vivo recordings in mice.

This study shows that FMRP depletion in human neurons causes cyclic-AMP-dependent hyperexcitability, which can be corrected by inhibiting phosphodiesterase 4D.

This study uses live human brain slice cultures to show that physiological and pathological amyloid-beta have opposing effects on synapses, with physiological levels enhancing synaptic transcripts and pathological levels causing synaptic loss.

This study quantifies how GABAB receptor signalling contributes to circuit-level inhibition in rat and human cortical principal cells across the lifespan, revealing age and species differences.

The paper identifies transmembrane protein 97 as a synaptic receptor for amyloid beta in human Alzheimer's disease using advanced microscopy and drug intervention studies.

The paper investigates synaptic and dendritic changes in a mouse model of tauopathy, finding altered synaptic integration and dendritic restructuring associated with early-stage tau pathology.

This study tracks synapse plasticity in tauopathy and finds that changes in synaptic structure precede neurite degeneration, with distinct patterns in axons and dendrites.