Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance.
Joe R. Harman, Ross Thorne, Max Jamilly, Marta Cecylia Tapia, Nicholas T. Crump, Siobhan Rice, Ryan D. D. Beveridge, Edward R. Morrissey, Marella F. T. R. De Bruijn, Irene A.G. Roberts, Anindita Roy, Tudor A. Fulga, Thomas A. Milne
The paper constructs a gene regulatory network for MLL-AF4 to reveal an indirect repression of CASP9 via RUNX1 as a mechanism of apoptosis resistance.
Genome Research · Jul 1, 2021Peer-reviewedGenomics