Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin's biochemical activity without changing thick filament structure
Saffie E. Mohran, Kristina Bezold Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Kyrah L. Turner, Weikang Ma, Galina V. Flint, Siyao Jiang, Jing Zhao, Timothy S. McMillen, Christian Mandrycky, Max Mahoney-Schaefer, Thomas C. Irving, Bertrand C.W. Tanner, , Farid Moussavi‐Harami
This paper shows Aficamten inhibits cardiac myosin ATPase without changing thick filament structure, unlike Mavacamten, leading to similar force reduction but different kinetic effects.
bioRxiv · May 14, 2025 · PreprintBiophysics