Author

Matvey Pilagov

University of KentORCID 0000-0002-1915-382XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:non-human primate· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ateeqa NaimiD· 4 shared Neil M. KadiD· 4 shared Michael A. GeevesiD· 3 shared Michael RegnieriD· 3 shared Christian MandryckyiD· 2 shared Farid Moussavi‐HaramiiD· 2 shared Jing ZhaoiD· 2 shared Kristina Bezold KooikeriD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

Ateeqa NaimORCID

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4 papers

Recent·Most cited

BiophysicsJournal of Molecular and Cellular CardiologyPeer-reviewedOct 28, 2025

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.

Sonette Steczina, Saffie E. Mohran, Matthew Carter Childers…·Michael Regnier

This study investigates the R403Q mutation in beta-myosin heavy chain using porcine and human stem cell models, revealing altered contractile properties and mechanisms of hypercontractility and impaired relaxation.

7 citationstop 4%

humanmouse

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BiophysicsJournal of Muscle Research and Cell MotilityPeer-reviewedOct 22, 2025

Direct measurement of mavacamten and deoxyATP perturbation of the SRX/DRX ratio in porcine cardiac myofibrils using a simple, accessible and multiplexed approach

Matvey Pilagov, Ateeqa Naim, Kenneth S. Campbell…·Neil M. Kad

The paper measures how mavacamten and deoxyATP affect the SRX/DRX ratio in porcine cardiac myofibrils using a fluorescence imaging approach.

1 citation

non-human primateimaging

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BiophysicsThe Journal of General PhysiologyPeer-reviewedJun 11, 2025

Spatially resolving how phosphorylation affects β-cardiac myosin activity in porcine myofibril sarcomeres with single molecule resolution

Matvey Pilagov, Sonette Steczina, Ateeqa Naim…·Neil M. Kad

This study uses single molecule imaging to analyze how phosphorylation affects myosin activity and cardiac reserve in porcine sarcomeres, identifying distinct kinetic states and their modulation by phosphorylation.

12 citationstop 2%

non-human primatefluorescence / live-cell microscopy

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BiophysicsbioRxivPreprintMay 14, 2025

Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin's biochemical activity without changing thick filament structure

Saffie E. Mohran, Kristina Bezold Kooiker, Ateeqa Naim…·Farid Moussavi‐Harami

This paper shows Aficamten inhibits cardiac myosin ATPase without changing thick filament structure, unlike Mavacamten, leading to similar force reduction but different kinetic effects.

3 citations

humanATAC-seq

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