Thomas C. Irving

This paper improves fiber diffraction pattern alignment by refining symmetry center and rotation using hybrid methods, achieving accuracy comparable to exhaustive search with faster runtime.

This paper uses polarized second-harmonic generation microscopy to analyze myosin states in hypertrophic cardiomyopathy, showing increased ON state fraction in mutated tissue.

This study compares the structural and functional properties of porcine left atrial and ventricular myosin filaments, revealing distinct calcium-dependent regulatory mechanisms between the two chambers.

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

This paper shows Aficamten inhibits cardiac myosin ATPase without changing thick filament structure, unlike Mavacamten, leading to similar force reduction but different kinetic effects.