Metazoan Orc6 Proteins Evolved Alternative Mechanisms for Association with the ORC Complex: Insights from Drosophila Modeling
Maxim Balasov, Etsuko Shibata, Katarina Akhmetova, Anindya Dutta, Igor N. Chesnokov
The paper investigates differences in Orc6 protein interactions with the ORC complex in Drosophila and humans, proposing that a nuclear localization signal in humans compensates for weaker binding.
Genetics · Oct 26, 2026Peer-reviewedMolecular Biology