Anindya Dutta

The paper investigates differences in Orc6 protein interactions with the ORC complex in Drosophila and humans, proposing that a nuclear localization signal in humans compensates for weaker binding.

The paper identifies tRF-3021a as a cancer-promoting tRNA-derived fragment that supports invasiveness, apoptosis resistance, and global protein synthesis in cancer cell lines.

PATTY corrects open chromatin bias in CUT&Tag data using ATAC-seq and machine learning, improving detection of histone modifications and cell clustering in single-cell analyses.

This study investigates the role of ORC2 in epigenetic regulation and chromosome structure through a multi-omics analysis of a human cell line with ORC mutations.

The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.

This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.

The paper shows diet intervention alters sncRNA expression in human sperm, linking paternal nutrition to offspring health through epigenetic changes.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

The paper analyzes DNA replication origins and ORC/MCM binding sites in human cells, finding minimal overlap and suggesting origins are specified by stochastic events rather than specific binding sites.

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.

The paper shows that human cancer cells can initiate DNA replication without ORC5 and ORC2 proteins, suggesting alternative mechanisms for MCM2-7 recruitment.

The paper shows that ATAC-seq can detect thousands of extrachromosomal circular DNAs in cancer and cell lines without specific enrichment.

The paper shows that the miR-206 family is not essential for myogenesis in vitro but affects mitochondrial function and muscle performance in vivo.

The paper identifies prognostic germline variants in 10,582 cancer patients using multivariate Cox regression, showing their association with patient outcomes beyond clinical data.

The paper examines tRNA-derived fragments (tRFs) and microRNAs in the maternal-fetal interface of a mouse model to assess their expression patterns and response to maternal immune activation.

This study shows ANG cleaves specific tRNAs to produce halves and tRF-5s, but stress-induced tRNA halves are mostly ANG-independent, and tRF-3s are not generated from tRNA halves or ANG cleavage.

The paper shows that microDNA produces regulatory RNAs that suppress gene expression through miRNA and si-like RNA mechanisms.

The paper develops a prognostic signature for lower-grade gliomas using lncRNA expression, showing it outperforms existing methods and identifies patients needing aggressive therapy.

The paper identifies tRF-3 fragments that repress gene expression through Argonaute-dependent seed sequence matching, independent of Dicer.