Interplay between human ribosomal proteins, PARP1, PARP2, HPF1 and histones
Andrey S. Krasnikov, Konstantin N. Naumenko, Mikhail M. Kutuzov, Yulia B. Zhakupova, Maxim O. Pavlov, Alexey A. Malygin, David Pastré, D. M. Graifer, Olga I. Lavrik
The paper investigates ADP-ribosylation of human ribosomal proteins by PARP1 and PARP2, showing that 60S subunit RPs are more modified and HPF1 enhances this modification, while core histones compete with RPs for PARylation.
bioRxiv · Sep 15, 2025 · PreprintMolecular Biology