Author
Institute of Chemical Biology and Fundamental MedicineORCID 0000-0003-0927-4043Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Danil M. Shtanov, Tatyana A. Kurgina, Mikhail M. Kutuzov…·Olga I. Lavrik
The paper shows that nucleosomes enhance DNA polymerase β activity in linker DNA and that PARP1/PARP2 regulate this activity and BER sub-pathway choice.
Anastasia S. Singatulina, Maria V. Sukhanova, Loïc Hamon…·Olga I. Lavrik
This study investigates how HPF1 modulates PARP1 and PARP2 activity to influence FUS-dependent compartment formation during DNA damage.
Aleksandr Andreevich Alekseev, Mikhail M. Kutuzov, Ekaterina A. Belousova…·O. I. Lavrik
The paper shows PARP1 binding weakens nucleosome core contacts using optical tweezers.
Andrey S. Krasnikov, Konstantin N. Naumenko, Mikhail M. Kutuzov…·Olga I. Lavrik
The paper investigates ADP-ribosylation of human ribosomal proteins by PARP1 and PARP2, showing that 60S subunit RPs are more modified and HPF1 enhances this modification, while core histones compete with RPs for PARylation.
Tatyana A. Kurgina, Nina A. Moor, Mikhail M. Kutuzov…·Olga I. Lavrik
This study investigates how structural features of damaged nucleosomes influence PARP1 and PARP2 activities in histone ADP-ribosylation during genotoxic stress.