Modulation of RNA polymerase processivity affects double-strand break repair in the presence of a DNA end-binding protein
Priya Sivaramakrishnan, Catherine C. Bradley, Irina Artsimovitch, Katelin M. Hagstrom, Laura Deus Ramirez, Alice X Wen, Matthew Brandon Cooke, Maya Shaulsky, Christophe Herman, Jennifer A. Halliday
This study shows that MuGam inhibits DNA break repair by slowing DNA resection and that GreA loss restores repair by releasing MuGam, linking transcription to DNA repair in E. coli.
bioRxiv · Feb 8, 2022 · PreprintMolecular Biology