Priya Sivaramakrishnan

This study investigates the distinct roles of TBX-35 and CEH-51 in C. elegans mesoderm lineage development using genetic and single-cell RNA sequencing approaches.

The paper identifies THPO, IGF1, and MAPK as therapeutic targets for mitochondrial respiratory chain disease and osteosarcoma, showing their modulation can replicate the benefits of CHX treatment.

The paper estimates absolute transcript accumulation rates in early C. elegans embryos using single-cell RNA sequencing and single molecule transcript imaging, showing rapid accumulation of transcription factor mRNAs and identifying core promoter motifs involved in this process.

The paper identifies regulatory mechanisms for posterior Hox genes nob-1 and php-3 in C. elegans, showing that anterior Hox gene ceh-13 and other factors activate these genes, influencing cell lineage and position.

This study shows that MuGam inhibits DNA break repair by slowing DNA resection and that GreA loss restores repair by releasing MuGam, linking transcription to DNA repair in E. coli.

The paper identifies specific bacterial metabolites affecting C. elegans physiology and develops an RNA interference strain to study genotype-phenotype interactions without microbial confounding.

The paper maps lineage and transcriptome relationships in C. elegans embryogenesis using single-cell transcriptomics, revealing lineage-transcriptome correlation breakdown in late divisions.