Irina Artsimovitch

The paper investigates how RfaH and NusG regulate RNA polymerase pausing during transcription of long operons in E. coli, showing RfaH extends transcription runs and compensates for NusA's pause-inducing effect.

The paper shows that Sfx, a histone-like protein in R6K plasmid, selectively silences the vir operon by forming stable nucleoprotein filaments and phase separating with plasmid DNA.

This study identifies the role of the ω subunit in stabilizing RNA polymerase to balance processivity and collision resolution during transcription.

The paper predicts RfaH homolog structures using AlphaFold2, identifies active-state homologs, and supports a stepwise evolutionary model of RfaH specialization.

This study shows that coronavirus polymerase template switching is driven by nsp13-helicase and is enhanced by remdesivir and molnupiravir, leading to defective RNA production.

The paper shows that the SARS-CoV-2 polymerase core RTC undergoes a conformational change after RNA binding to become elongation-competent, which is essential for viral RNA synthesis.

This study shows that MuGam inhibits DNA break repair by slowing DNA resection and that GreA loss restores repair by releasing MuGam, linking transcription to DNA repair in E. coli.

The paper investigates how phosphorylated nucleotides like remdesivir triphosphate and ppGpp activate SARS-CoV-2 RdRp through allosteric mechanisms involving the NiRAN domain and Nsp7/8 subunits.

This paper investigates how SutA, a small protein in Pseudomonas aeruginosa, modulates transcription initiation during growth arrest by interacting with RNA polymerase.

The paper introduces a streptavidin roadblocking strategy to improve cotranscriptional SHAPE-seq for RNA folding studies and demonstrates its application to the Bacillus cereus crcB fluoride riboswitch.