Author

Mayu Shimomura

University of Toronto

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Biology Disciplines

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Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1

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Haley D.M. WyattiD· 1 shared Hwa Young Yun· 1 shared Jared T. SimpsoniD· 1 shared Philip C. ZuzarteiD· 1 shared Thomas R. HurdiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperDevelopmental Biology

Haley D.M. WyattORCID

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1 paper

Recent·Most cited

A structure-selective endonuclease drives uniparental mitochondrial DNA inheritance

Mayu Shimomura, Hwa Young Yun, Philip C. Zuzarte, Jared T. Simpson, Haley D.M. Wyatt, Thomas R. Hurd

The paper identifies Hotaru, a testis-specific endonuclease, as essential for paternal mtDNA elimination in sperm, revealing its structural recognition of mtDNA cruciform DNA.

bioRxiv · Mar 20, 2026 · PreprintDevelopmental Biology