Haley D.M. Wyatt

This study shows that Dna2 forms condensates that enhance DNA end resection in yeast, with phosphorylation regulating condensate stability and function.

The paper identifies Hotaru, a testis-specific endonuclease, as essential for paternal mtDNA elimination in sperm, revealing its structural recognition of mtDNA cruciform DNA.

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

The paper introduces a CRISPR-based system called qTAG to improve the efficiency and flexibility of endogenous protein tagging through optimized repair cassettes.

This study develops a yeast whole-cell biocatalyst expressing MHETase for PET degradation, showing comparable activity to purified enzyme and stability under various conditions.

This study shows that Rad52 proteins in yeast form liquid droplets that facilitate DNA repair by tethering damaged DNA to microtubules.