Philip C. Zuzarte

Decoding the naked mole-rat genome, telomere to telomere

The paper presents a telomere-to-telomere genome assembly of the naked mole-rat and compares it with a related species to identify gene losses and duplications associated with unique traits.

Multi-platform reassessment of human mitochondrial DNA methylation reveals signals consistent with technical artifacts

This study reassesses human mitochondrial DNA methylation using multiple platforms and finds signals likely due to technical artifacts rather than biological methylation.

A structure-selective endonuclease drives uniparental mitochondrial DNA inheritance

The paper identifies Hotaru, a testis-specific endonuclease, as essential for paternal mtDNA elimination in sperm, revealing its structural recognition of mtDNA cruciform DNA.

Plasma cell-free DNA methylome as early detection and prognostic marker for pancreatic cancer

This study identifies cell-free DNA methylation markers for early detection and prognosis of pancreatic cancer with high accuracy and survival stratification.

An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology

The paper presents an updated reference genome for the naked mole-rat, identifying gene losses and gains linked to its unique physiological traits.

Nanopore native RNA sequencing of a human poly(A) transcriptome

The paper uses nanopore sequencing to analyze poly(A) RNA from human cells, identifying long transcripts and modifications not captured by traditional methods.

Identifying TCDD-resistance genes via murine and rat comparative genomics and transcriptomics

The paper identifies genes associated with TCDD-response phenotypes by comparing genomic and transcriptomic data from transgenic mice and rats.