Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans
Daniel A. Skelly, John P. Graham, Mingshan Cheng, Mayuko Furuta, Andrew Walter, Thomas A. Stoklasek, Hongyuan Yang, Timothy M. Stearns, Olivier Poirion, Jigang Zhang, Jessica D. S. Grassmann, Diane Luo, William F. Flynn, Elise T. Courtois, Chih-Hao Chang, , Edison T. Liu
The paper identifies host genetic factors influencing anti-PD-1 response in mice and humans by mapping QTLs and finding a core gene network with prognostic value in human tumors.
Cell Reports · May 1, 2025Peer-reviewedCancer Biology