Edison T. Liu

The paper compares mouse and human tumor microenvironments, identifying conserved and species-specific features in immune composition and gene expression programs.

The paper shows that defective BRCA1-mediated DNA end resection leads to Group 1 tandem duplication formation and FANCM synthetic lethality in mouse models.

The paper identifies host genetic factors influencing anti-PD-1 response in mice and humans by mapping QTLs and finding a core gene network with prognostic value in human tumors.

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

Cellos is a high-throughput image analysis pipeline for 3D organoid segmentation and analysis, enabling accurate quantification of drug responses and cell interactions in cancer organoids.

This study identifies FANCM's role in regulating repair pathway choice at stalled replication forks and highlights its ATPase function as a potential therapeutic target for BRCA1 mutant cancers.

This study investigates how PML/RARα alters chromatin topology and transcription in APL cells, revealing its role in repressing myeloid differentiation genes.

The paper identifies three span intervals of tandem duplications in TDP tumors and links them to specific gene mutations and pathways, showing TP53 and BRCA1 loss drives short-span TDPs.

This study uses nanopore sequencing to identify structural variants in breast cancer with high specificity and sensitivity, revealing repetitive DNA as a major source of variation.

This study quantifies intratumoral subclone dynamics in breast cancer xenografts, revealing a treatable ecology where subclone ratios predict treatment response.