Author

Mazen Makke

Saarland University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Dieter BrunsiD· 2 shared Aidan V. JohnsoniD· 1 shared Alejandro Pastor Ruiz· 1 shared Alin Sebastian PoraviD· 1 shared Andreas Ohlenbusch· 1 shared Antonio Yarzagaray· 1 shared ChungKu LeeiD· 1 shared Claudia C. BaueriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Dieter BrunsORCID

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3 papers

Recent·Most cited

ATP1A3 E815K Disrupts Sodium Homeostasis and Excitability in Human Alternating Hemiplegia of Childhood Neurons

Mazen Makke, ChungKu Lee, Elinor Lazarov, HongJun Rhee, Andreas Ohlenbusch, Lukas Cyganek, Maria-Patapia Zafeiriou, Jutta Gaertner, JeongSeop Rhee, Hendrik Rosewich

This study investigates the impact of the ATP1A3 E815K mutation on human neurons, showing disrupted sodium homeostasis and altered excitability.

bioRxiv · Oct 11, 2026 · PreprintNeuroscience

Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues

Markus Müller, Konstantin Niemeyer, Navin Kumar Ojha, Alin Sebastian Porav, Deivanayagabarathy Vinayagam, Nicole D. Urban, Fanny Büchau, Katharina Oleinikov, Mazen Makke, Claudia C. Bauer, Aidan V. Johnson, Stephen P. Muench, Frank Zufall, Dieter Bruns, Yvonne N. Schwarz, , Oliver Thorn‐Seshold

This paper develops and tests ideal efficacy photoswitch ligands for TRPC4/5 channels, enabling precise spatiotemporally-controlled modulation in live tissues.

Nature Chemical Biology · Jan 16, 2026Peer-reviewedCell Biology

Key determinants of the dual clamp/activator function of Complexin

Mazen Makke, Alejandro Pastor Ruiz, Antonio Yarzagaray, Surya Gaya, Michelle Zimmer, Walentina Frisch, Dieter Bruns

This study identifies key molecular features of Complexin II that regulate vesicle fusion timing by interacting with SNARE proteins and synaptotagmin I.

eLife · Nov 25, 2024Peer-reviewedNeuroscience