Lukas Cyganek

This study investigates the impact of the ATP1A3 E815K mutation on human neurons, showing disrupted sodium homeostasis and altered excitability.

This study shows that AMPK activation rescues mitochondrial function and structural remodeling in TMEM70-deficient cardiomyocytes, highlighting a metabolic rescue mechanism in mitochondrial cardiomyopathy.

This study identifies unique mtDNA mutation patterns in TOP3A-deficient cardiomyocytes, linking mtDNA instability to mitochondrial dysfunction in cardiac disease.

This study shows that variant U1 snRNAs affect gene expression and cell cycle in human iPS cells through alternative splicing changes.

This study shows that peroxisome dysfunction in mice and engineered human myocardium leads to heart failure through metabolic impairment and disrupted cellular respiration.

SarcAsM provides a multiscale analysis tool for sarcomere structure and dynamics in cardiomyocytes using deep learning and graph-based methods.

This study shows that BTRR complex deficiency increases genomic instability through copy number alterations, enriched at fragile sites, using CRISPR-edited iPSC models.

The paper introduces tools to selectively enhance Gi/o-mediated GIRK currents in excitable cells using light-activated GPCRs.

CardioMEA is a data-analysis platform for HD-MEA data from iPSC-CMs, enabling electrophysiological analysis of cardiac diseases and drug responses.

This study uses single-cell transcriptome analysis to show that BLM deficiency in Bloom syndrome patients alters gene expression related to mitosis, genomic instability, and condensin complexes.