Author

Megan C. Sikes

Seattle Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:dimensionality reduction· 1 Assay:long-read sequencing· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dan DohertyiD· 2 shared Danny E. MilleriD· 2 shared Jessica X. ChongiD· 2 shared Katrina M. DippleiD· 2 shared Michael J. BamshadiD· 2 shared Abbey A. ScottiD· 1 shared Alexandra KeefeiD· 1 shared Alexandra P. LewisiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Dan DohertyORCID

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2 papers

Recent·Most cited

SeqFirst: Building equity access to a precise genetic diagnosis in critically ill newborns

Tara Lynn Wenger, Abbey A. Scott, Lukas Kruidenier, Megan C. Sikes, Alexandra Keefe, Kati J. Buckingham, Colby T. Marvin, Kathryn M. Shively, Tamara J. Bacus, Olivia M. Sommerland, Kailyn Anderson, Heidi I. S. Gildersleeve, Chayna J. Davis, Jamie A. Love-Nichols, Katherine E. MacDuffie, , Michael J. Bamshad

SeqFirst-neo uses a genotype-driven workflow with broad exclusion criteria to increase access to rapid whole genome sequencing in critically ill newborns, significantly improving the rate and equity of precise genetic diagnoses.

The American Journal of Human Genetics · Feb 24, 2025Peer-reviewedGenetic & Genomic Medicine

Targeted long-read sequencing resolves complex structural variants and identifies missing disease-causing variants

Danny E. Miller, Arvis Sulovari, Tianyun Wang, Hailey Loucks, Kendra Hoekzema, Katherine M. Munson, Alexandra P. Lewis, Edith P. Almanza Fuerte, Catherine Randall Paschal, Jenny M. Thies, James T. Bennett, Ian Glass, Katrina M. Dipple, Karynne Patterson, Emily S. Bonkowski, , Evan E. Eichler

This paper introduces targeted long-read sequencing to identify complex structural variants and disease-causing mutations missed by conventional methods, improving diagnostic accuracy in genetic disorders.

bioRxiv · Nov 3, 2020 · PreprintGenomics