Tianyun Wang

NeuroPilot: Longitudinal intravital neural imaging across scales and modalities through an agentic platform

NeuroPilot converts heterogeneous intravital neural recordings into stable population activity maps, enabling behavioral decoding and structured neural dynamics analysis across behavioral states.

IGF2BP2 links m6A-modified HMGA1 mRNA stability to mitochondrial metabolism and cell proliferation

This study shows IGF2BP2 enhances recombinant protein yield in CHO cells by stabilizing HMGA1 mRNA and improving mitochondrial metabolism and cell proliferation.

Three-dimensional spatial transcriptomics at isotropic resolution enabled by generative deep learning

This paper introduces isoST, a deep learning framework that infers isotropic 3D gene expression from sparse 2D spatial transcriptomics data, enabling accurate 3D reconstruction of tissues and uncovering spatial gradients missed in 2D analyses.

Targeted long-read sequencing resolves complex structural variants and identifies missing disease-causing variants

This paper introduces targeted long-read sequencing to identify complex structural variants and disease-causing mutations missed by conventional methods, improving diagnostic accuracy in genetic disorders.

Recent ultra-rare inherited mutations identify novel autism candidate risk genes

The paper identifies ultra-rare inherited mutations that are younger and preferentially transmitted to autism probands, revealing novel candidate genes and functional networks.