Ian Glass

Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development

The paper compares mesenchymal cell development in mouse and human intestines using scRNA-seq, finding conserved cell types but differing lineage-defining genes.

Mapping mesenchymal diversity in the developing human intestine and organoids

The paper maps mesenchymal diversity in the developing human intestine and organoids using single-cell RNA-sequencing and spatial transcriptomics, identifying distinct fibroblast populations and their spatial organization.

Saturation genome editing of RNU4-2 reveals distinct dominant and recessive neurodevelopmental disorders

This study uses saturation genome editing to analyze RNU4-2 variants, identifying functional impacts and redefining the ReNU syndrome critical region.

Distinct airway progenitor cells drive epithelial heterogeneity in the developing human lung

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

Targeted long-read sequencing resolves complex structural variants and identifies missing disease-causing variants

This paper introduces targeted long-read sequencing to identify complex structural variants and disease-causing mutations missed by conventional methods, improving diagnostic accuracy in genetic disorders.