A Fob1 independent role for the Smc5/6 complex in the rDNA that modulates lifespan.
Sarah Moradi‐Fard, Aditya Mojumdar, Megan Chan, Troy A. A. Harkness, Jennifer A. Cobb
The paper shows Smc5/6 complex functions in rDNA transcriptional silencing and repeat tethering, affecting lifespan independently of Fob1 and HR processing at the RFB.
bioRxiv · Jan 24, 2020 · PreprintMolecular Biology