Jennifer A. Cobb

Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA

The paper develops a nanobody that selectively blocks EFR3 recruitment of PI4KA by targeting TTC7B, reducing membrane recruitment and PI4P production.

Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks

This study shows that Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks, promoting resection and accurate repair.

Intrinsic disorder specifies discreet functions of nucleoplasmin-like histone chaperones

The paper investigates the role of intrinsically disordered regions (IDRs) in nucleoplasmin-like histone chaperones, finding that some functions require IDRs while others do not.

SIR telomere silencing depends on nuclear envelope lipids and modulates sensitivity to a lysolipid drug

This study shows that lysolipid treatment alters NE lipid composition, reducing Sir4 telomere association and triggering lipid-specific transcriptional changes in yeast.

Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.

This study shows that aging leads to decreased DNA resection and increased end-joining repair, resulting in more genomic mutations in yeast.

Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice

The paper investigates the role of Nej1's C-terminus in DNA double-strand break repair pathway choice and end-joining, identifying key residues that influence NHEJ and inhibit resection.

Nej1XLF interacts with Sae2CTIP to inhibit Dna2 mediated resection at DNA doublestrand break

The paper identifies Nej1's interaction with Sae2 and its role in inhibiting DNA resection at DSBs, affecting repair pathway choice and outcomes.

Modeling Cancer Genomic Data in Yeast Reveals Selection Against ATM Function During Tumorigenesis

The paper models mutations in the Mre11 complex in yeast to show that defects in ATM signaling, rather than DNA repair, are more critical for tumor suppression.

A Fob1 independent role for the Smc5/6 complex in the rDNA that modulates lifespan.

The paper shows Smc5/6 complex functions in rDNA transcriptional silencing and repeat tethering, affecting lifespan independently of Fob1 and HR processing at the RFB.