Troy A. A. Harkness

Discovery of a small peptide that activates both APCCdc20 and APCCdh1 in yeast, driving increased lifespan

The paper identifies a small peptide, C43-4, that activates the APC Cdh1 complex in yeast, increasing chronological lifespan and showing evolutionary conservation in C. elegans.

The Anaphase Promoting Complex targets the toxic protein Progerin for ubiquitin-dependent degradation via autophagy

This study identifies the Anaphase Promoting Complex (APC) as a mediator of progerin degradation via autophagy in Hutchinson-Gilford Progeria Syndrome.

A Fob1 independent role for the Smc5/6 complex in the rDNA that modulates lifespan.

The paper shows Smc5/6 complex functions in rDNA transcriptional silencing and repeat tethering, affecting lifespan independently of Fob1 and HR processing at the RFB.

Rapid nuclear exclusion of Hcm1 in aging Saccharomyces cerevisiae leads to vacuolar alkalization and replicative senescence

The paper shows that Hcm1 nuclear exclusion in aging yeast leads to vacuolar alkalization and reduced replicative lifespan.