Design, Amino-Acid-Derived Analogues of FTY-720 and OSU-2S as PP2A Activators: Structure-Activity Relationships and Identification of Lead Compound XML-3D
Rui Yang, Noura Srour, Pankajavalli Thirugnanasambandam, Shabber Mohammed, Megan E. Roderick, Santhanam Ramasamy, Ann Ventura, Enming Xing, Jeffrey Cheng, Xiaolin Cheng, Aiden Tamulonis, Dharani Mayilsamy, Anuvrat Sarkar, Lalit Sehgal, Natarajan Muthusamy, Pui-Kai Li
The paper designs and evaluates amino-acid-derived PP2A activators, identifies XML-3D as a lead compound with improved cytotoxicity compared to FTY-720 and OSU-2S.
bioRxiv · Oct 14, 2026 · PreprintMolecular Biology